Recent Advances in Assessing Glymphatic System Function in Neurological Diseases Based on DTI-ALPS Method

类淋巴系统(glymphatic system, GS)是大脑的废物清除途径，对维持中枢神经系统的内环境稳态至关重要。近年来，沿血管周围间隙的弥散张量成像(diffusion tensor imaging analysis along the perivascular space, DTI-ALPS)作为一种无创非侵入性成像技术，被广泛应用于各种神经系统疾病的GS功能评估，利用DTI-ALPS方法计算出的ALPS指数能反映疾病的动态变化。本文就GS的结构和功能、DTI-ALPS的原理和优势及其在神经系统疾病中的应用进行综述，旨在为神经系统疾病的病程监测、疗效评估和预后预测等提供一定的参考依据。The glymphatic system (GS) plays a vital role in clearing waste from the brain, which is essential for maintaining the homeostasis of the central nervous system. In recent years, diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) has emerged as a valuable non-invasive imaging technique for assessing GS function in various neurological disorders. The ALPS index derived from DTI-ALPS can capture dynamic changes associated with these diseases. This article reviews the structure and function of the GS, the principles and benefits of DTI-ALPS, and its application in neurological diseases, aiming to provide a reference for monitoring disease progression, evaluating therapeutic efficacy, and predicting prognosis in neurological disorders.