Four Alkaloids from <i>Alstonia scholaris</i> with Antitumor Activity via Disturbing Glutathione Homeostasis
Alstoschoquinolines A-D (<b>1</b>-<b>4</b>) representing three unprecedented scaffolds were isolated from the leaves of <i>Alstonia scholaris</i> through direct separation by LC/MS detection. <b>1</b> and <b>2</b> consisted of a 5/6/5-coupled quinoline architecture containing six consecutive chiral carbons, while <b>3</b> and <b>4</b> possessed a bridged ring featuring 6/6/6/6 and 6/6/8/6 skeletons, respectively. They might be derived from the corynantheine-type indole alkaloid via sequential oxidation and rearrangement. Compound <b>3</b> exhibited a significant inhibitory effect on colon carcinoma cells by disturbing glutathione circulation.
Authors
- Lanchun Zhang (ORCID: https://orcid.org/0000-0001-6615-4414)
- Xin Wei (ORCID: https://orcid.org/0000-0001-8361-9877)
- Khalid-Hassan Mohamed (ORCID: https://orcid.org/0009-0007-6837-4534)
- Guiguang Cheng (ORCID: https://orcid.org/0000-0002-5553-8399)
- Xiao‐Dong Luo
- Rongping Zhang (ORCID: https://orcid.org/0000-0002-0349-2982)
- Caifeng Ding (ORCID: https://orcid.org/0000-0002-5281-0158)
- Yaping Liu (ORCID: https://orcid.org/0000-0002-2164-2489)
- Zhi Dai
- Haofei Yu
Institutions
- Kunming University of Science and Technology (CN)
- Kunming Institute of Botany (CN)
- Yunnan University (CN)
- Chinese Academy of Sciences (CN)
- Kunming Medical University (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1021/acs.joc.4c02450
- Citations
- 5
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 7.79
Funders
- Major Science and Technology Projects in Yunnan Province