Dissociation of <scp>IgM</scp> antibodies from red blood cells using ethylenediamine tetraacetate/glycine acid or chloroquine diphosphate
EGA could dissociate cold-reactive antibodies, whereas CDP had a higher residual antibody content. This difference in dissociation ability appears to correlate with the antibody pH of the dissociation reagent. EGA treatment may be useful in cases of sensitization by high-titer cold-reactive antibodies.
Authors
- Yasuo Miura (ORCID: https://orcid.org/0000-0001-9654-1300)
- Yuko Abe (ORCID: https://orcid.org/0009-0007-1207-1227)
- Hideaki Matsuura (ORCID: https://orcid.org/0000-0001-6307-3379)
- Yuya Ishihara (ORCID: https://orcid.org/0000-0002-8066-7344)
- Sumie Fujii
- Ayuna Yamada
- H. Kojima
- Hiroki Doi
- Rie Nakagawa
Institutions
- Fujita Health University (JP)
- Fujita Health University Hospital (JP)
Publication Details
- Journal
- Transfusion
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1111/trf.18128
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00