AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice
AM1241 inhibited activation of the NF-κB signaling pathway via activating Nrf2. It suppressed the expression of inflammation factors and the degradation of ECM in vitro, and improved OA in mice in vivo, suggesting its potential as an effective drug candidate for the treatment of OA. The remarkable efficacy of AM1241 in alleviating murine OA positions it as a potential therapeutic strategy in the clinical management of OA diseases.
Authors
- Zhuan Zou (ORCID: https://orcid.org/0000-0002-7744-7236)
- Changzheng Sun
- Songmu Pan
- Jinmin Zhao (ORCID: https://orcid.org/0000-0001-7509-0977)
- Kai Xiao (ORCID: https://orcid.org/0000-0002-7526-4233)
- Jiyong Wei
- Yi Xu (ORCID: https://orcid.org/0000-0002-3936-216X)
- Ronghe Gu (ORCID: https://orcid.org/0009-0006-8456-308X)
Institutions
- Guangxi Medical University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1186/s10020-024-01012-5
- Citations
- 9
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 15.01
Funders
- Natural Science Foundation of Guangxi Province