Formulation development and in vitro evaluation of terbutaline floating tablets

The present study outlines a systematic approach for designing and development of Terbutaline floatingtablets to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablets of Terbutaline haveshown sustained release thereby proper duration of action at a particular site and are designed to prolong thegastric residence time after oral administration. Different formulations were formulated by using direct compression method. A floating drug delivery system (FDDS) was developed by using sodium bicarbonate asgas-forming agent and HPMC E5, Eudragit RLPO and Sodium carboxy methylcellulose as polymers. The prepared tablets wereevaluated in terms of their physical characteristics, precompression parameters, in vitro release and buoyancylag time. The results of the in vitrorelease studies showed that the optimized formulation (T7) could sustaindrug release for 12 hrs by using Sodium carboxy methylcellulose in the concentration of 5mg. The in vitro drug release followed zero order kinetics.