Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis
There are significant differences in mitochondrial structure, ATP production and mitochondria-related gene expression between adult- and elderly-onset UC, which have a potential link with cytokine pathways and immune microenvironment. The more prominent mitochondrial injury may be a key factor for more severe inflammatory response and poorer outcome in elderly-onset UC.
Authors
- Xiaoyin Bai (ORCID: https://orcid.org/0000-0002-9092-7592)
- Hong Yang (ORCID: https://orcid.org/0000-0003-0869-3369)
- Hong Lv (ORCID: https://orcid.org/0000-0002-6624-1742)
- Jiaming Qian (ORCID: https://orcid.org/0000-0003-0474-5010)
- Qing Li (ORCID: https://orcid.org/0000-0003-2652-6070)
- Mengmeng Zhang (ORCID: https://orcid.org/0000-0001-7632-7702)
- Kai Lin
- Gechong Ruan
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Immunity & Ageing
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1186/s12979-024-00494-5
- Citations
- 3
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Natural Science Foundation of China
- Peking Union Medical College Hospital
- Peking Union Medical College