Impulsivity behaviors and white matter mediate the relationship between genetic risk for cannabis use disorder and early cannabis use in adolescents
The genetic risk of adult cannabis use disorder appears to be associated with substance use behavior and white matter structure as early as age 14. The observed mediation effect is consistent with the notion that genetic risk increases novelty seeking in a way that leads to more cannabis use in adolescents.
Authors
- Peter Callas (ORCID: https://orcid.org/0000-0002-3840-4081)
- Andreas Heinz (ORCID: https://orcid.org/0000-0001-5405-9065)
- Sylvane Desrivières (ORCID: https://orcid.org/0000-0002-9120-7060)
- Hugh P Garavan (ORCID: https://orcid.org/0000-0002-8939-1014)
- Rüdiger Brühl (ORCID: https://orcid.org/0000-0003-0111-5996)
- Tomáš Paus (ORCID: https://orcid.org/0000-0003-1495-9338)
- Renata B. Cupertino (ORCID: https://orcid.org/0000-0002-3452-0632)
- Sarah Elizabeth Medland (ORCID: https://orcid.org/0000-0003-1382-380X)
- Tobias Banaschewski (ORCID: https://orcid.org/0000-0003-4595-1144)
- Jonatan Ottino‐González (ORCID: https://orcid.org/0000-0003-2910-9926)
- Sarah Hohmann (ORCID: https://orcid.org/0000-0002-5175-6698)
- Jean‐Luc Martinot (ORCID: https://orcid.org/0000-0002-0136-0388)
- Marie‐Laure Paillère Martinot (ORCID: https://orcid.org/0000-0002-0452-2450)
- Arun L.W. Bokde (ORCID: https://orcid.org/0000-0003-0114-4914)
- Juliane H. Fröhner (ORCID: https://orcid.org/0000-0002-8493-6396)
- Herta Flor (ORCID: https://orcid.org/0000-0003-4809-5398)
- Antoine Grigis (ORCID: https://orcid.org/0000-0001-7984-3710)
- Robert Whelan (ORCID: https://orcid.org/0000-0002-2790-7281)
- Henrik Walter (ORCID: https://orcid.org/0000-0002-9403-6121)
- Patricia Conrod (ORCID: https://orcid.org/0000-0002-5570-481X)
- Luise Poustka (ORCID: https://orcid.org/0000-0002-7738-4394)
- Anthony Juliano (ORCID: https://orcid.org/0000-0001-7433-6891)
- Hervé Lemaître (ORCID: https://orcid.org/0000-0002-5952-076X)
- Michael N. Smolka (ORCID: https://orcid.org/0000-0001-5398-5569)
- Dimitri Papadopoulos Orfanos (ORCID: https://orcid.org/0000-0002-1242-8990)
- Scott Mackey (ORCID: https://orcid.org/0000-0001-7817-7437)
- Frauke Nees (ORCID: https://orcid.org/0000-0002-7796-8234)
- Devarshi Pancholi (ORCID: https://orcid.org/0009-0004-9698-6069)
- Penny Anne Gowland (ORCID: https://orcid.org/0000-0002-4900-4817)
- Eric Artiges A (ORCID: https://orcid.org/0000-0003-4461-7646)
- Zhipeng Cao (ORCID: https://orcid.org/0009-0007-2136-2296)
- Günter Schumann (ORCID: https://orcid.org/0000-0002-7740-6469)
Institutions
- University of Vermont (US)
- Physikalisch-Technische Bundesanstalt (DE)
- Centre National de la Recherche Scientifique (FR)
- Children's Hospital of Los Angeles (US)
- University of Nottingham (GB)
- Université de Bordeaux (FR)
- Inserm (FR)
- University of Mannheim (DE)
- King's College London (GB)
- University of Toronto (CA)
- Trinity College Dublin (IE)
- QIMR Berghofer Medical Research Institute (AU)
- Heidelberg University (DE)
- Fudan University (CN)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- University Hospital Heidelberg (DE)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- École Normale Supérieure - PSL (FR)
- Christian-Albrechts-Universität zu Kiel (DE)
- University of California San Diego (US)
- Humboldt-Universität zu Berlin (DE)
- Sorbonne Université (FR)
- Institut des Maladies Neurodégénératives (FR)
- Central Institute of Mental Health (DE)
- Pitié-Salpêtrière Hospital (FR)
- CEA Paris-Saclay (FR)
- Laboratoire de Biologie et Pharmacologie Appliquée (FR)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- Université de Montréal (CA)
- Freie Universität Berlin (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Addiction
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1111/add.16750
- Citations
- 4
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 5.44
Funders
- National Institute for Health and Care Research
- National Natural Science Foundation of China
- Horizon 2020 Framework Programme
- Medical Research Council