Review on Mycobacterium bovis in Host Immune Response Interactions and Omics Integrative Approaches in Infection

Bovine tuberculosis economically important disease with a wide range of host throughout globally.Mycobacterium bovis is the causative agent which transmissible in between species or within species.Among from route of transmission, aerosol inhalation is the primary one.The virulence and host factors is the key to determine infections and broadly to control the mode of transmission.Today infectious disease easily identified and characterized.Similarly, antibiotics and vaccines discovery simplified based on omics analysis and development of bioinformatics tools.So, Transcriptome was considered as the most informative assay in order to start with functional genomics to explore the relationship between genotype and phenotype of an individual.Transcriptome analyses were used to understand the mechanisms of pathogenesis of a disease and genes responsible for protective immune responses.Genes associated with specific diseases known as biomarkers can be determined.Using proteomics protein expression can be described in 3D structure and protein functions characterize by the role of proteins, glycoprotein and how proteins were expressed and the overall proteome at the level of macrophages, DC and lymphocytes cells or tissues were affected in response to M. bovis infection.