Formulation And Evaluation Of Indomethacin Liposomes

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. The objective of the present study was to formulate and evaluate liposomes loaded with Indomethacin. Liposome of Indomethacin was made by thin film hydration method. Phospholipids and cholesterol were used to make multilamellar vesicles. Six batches of liposomes were prepared based on the different weight ratio of Phospholipids and cholesterol. Differential scanning calorimetry (DSC) study conducted to study in any incompatibility. Liposomes were produced by the thin-film hydration method. Six formulations of liposomes were prepared by varying the concentrations of Phospholipids and cholesterol and changing the drug ratio. The obtained liposomes were characterized for surface morphology, FTIR, particle size, zeta potential, drug content, entrapment efficiency, and in-vitro diffusion studies. Among the Six formulations of liposomes, F5 was found to be the best formulation with entrapment efficiency of 85.81% and a zeta potential value of -28.4mV. Liposomes followed Peppas release kinetics. Indomethacin loaded liposomes were prepared with good stability and the highest entrapment efficiency