Innovative piperidone derivatives: a new horizon in Potent anticancer therapeutics

Recent advancements in the synthesis and evaluation of piperidone derivatives have unveiled their remarkable potential as potent anticancer agents. This review highlights the innovative approaches and significant findings in the development of novel piperidone-based compounds, showcasing their efficacy against various cancer cell lines. Among the noteworthy compounds, dissymmetric 3,5-bis(arylidene)-4-piperidones (BAPs) have demonstrated selective cytotoxicity with minimal impact on normal cells. Further, modifications involving N-benzoylation, N-benzenesulfonylation and N-acryloylation have enhanced the cytotoxic profiles of these derivatives, revealing significant activity against carcinoma, leukaemia, and colon cancer cell lines. QSAR studies and computer docking simulations have provided insights into the structural requirements for optimizing anticancer potency and selectivity. In vivo studies confirm the therapeutic potential of key compounds, demonstrating tumour growth inhibition with minimal toxicity. This comprehensive review underscores the transformative potential of piperidone derivatives, paving the way for their development as next-generation anticancer therapeutics.