NLRP3 deficiency aggravated DNFB-induced chronic itch by enhancing type 2 immunity IL-4/TSLP-TRPA1 axis in mice
These findings suggested that the absence of Nlrp3 aggravated DNFB-induced chronic itch by exacerbating type 2 immunity in the skin and enhancing the IL-4/TSLP-TRPA1 axis, potentially driven by reduced IL-18 levels.
Authors
- Zi Li (ORCID: https://orcid.org/0000-0002-1358-6421)
- Yang Tang (ORCID: https://orcid.org/0000-0003-1622-3199)
- Fan Yang (ORCID: https://orcid.org/0000-0002-0520-5254)
- Zuo-Ming Chen
- Zhe Peng (ORCID: https://orcid.org/0000-0002-3431-4409)
- Li Wan (ORCID: https://orcid.org/0000-0002-8729-4018)
- Siting Huang (ORCID: https://orcid.org/0000-0002-4230-7735)
- Yu Wang (ORCID: https://orcid.org/0000-0001-7811-5834)
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3389/fimmu.2024.1450887
- Citations
- 3
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 6.01
Funders
- Guangzhou Medical University
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Higher Education Discipline Innovation Project