Association of antihypertensive drug target genes with alzheimer’s disease: a mendelian randomization study
There findings suggest an adverse association of lower ACE messenger RNA and protein levels with an elevated risk of AD, irrespective of its BP-lowering effects. These findings warrant greater pharmacovigilance and further investigation into the effect of ACE inhibitors, particularly those that are centrally acting, on neurodegenerative symptoms in patients with AD.
Authors
- Yingqing Feng (ORCID: https://orcid.org/0000-0003-0443-5506)
- Chaolei Chen (ORCID: https://orcid.org/0000-0003-3557-0161)
- He Zheng (ORCID: https://orcid.org/0009-0001-8594-4910)
Institutions
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1186/s13195-025-01671-4
- Citations
- 5
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 9.09
Funders
- Guangdong Provincial People's Hospital
- National Science and Technology Major Project