Potential Effects of Levels of Vitamin C and Vitamin D in Serum on Diabetic Cardiovascular Diseases Prevention

Diabetes, as one of the major causes of global death, is affecting people worldwide and increasing the risk of cardiovascular diseases. Recent research indicated that vitamin C and vitamin D supplements can lower blood glucose levels and blood pressure to help prevent diabetic cardiovascular disease. However, the impact of the serums level of vitamin C and vitamin D on reducing the diabetic cardiovascular disease risk have not been fully illustrated. This paper aimed to investigate the association between vitamin C, vitamin D serum levels and cardiovascular disease complicated by diabetic mellitus. This study used data from the NHANES 2017-2018, and Multiple Linear Regression and Logistic Regression methods were implied. The study found that for plasma fasting glucose, vitamin D in serum was found to have a significant influence (p=0.0374). For blood pressure, significant correlations were observed with vitamin D in serum (p_Systolic<0.0001, p_Diastolic=0.0240) and with vitamin C in serum (p_Systolic<0.0001,p_Diastolic=0.0089). Furthermore, the impact of vitamin D serum levels on decreasing diabetic cardiovascular disease risks had a precondition, with serum content below sufficient standard 75 nmol/L provided by Americans Endocrine Society. SHAP was also applied in this paper as an interpretation was to support the findings. Future studies will explore the appropriate serum levels of vitamin C and vitamin D for clinical treatment.