A novel benzothiazole-1,2,3-triazole-based arene osmium(<scp>ii</scp>) complex as an effective rhabdomyosarcoma cancer stem cell agent
This is the first report of an osmium-based compound showing activity against CSC-enriched rhabdomyosarcoma (RD) cells, primarily caused by damage to cell membranes.
Authors
- Hana Kostrhunová (ORCID: https://orcid.org/0000-0003-2706-6491)
- José Ruiz (ORCID: https://orcid.org/0000-0002-0834-337X)
- Jana Kašpárková (ORCID: https://orcid.org/0000-0002-5279-5381)
- Lenka Marková (ORCID: https://orcid.org/0000-0003-1640-6163)
- M. Dolores Santana (ORCID: https://orcid.org/0000-0002-1446-8232)
- Alba Hernández-García (ORCID: https://orcid.org/0000-0002-6939-4787)
- Viktor Brabec (ORCID: https://orcid.org/0000-0002-8233-1393)
- Delia Bautista
- Sofia Sharkawy (ORCID: https://orcid.org/0009-0009-3032-953X)
Institutions
- Masaryk University (CZ)
- Czech Academy of Sciences, Institute of Biophysics (CZ)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Palacký University Olomouc (CZ)
- Universidad de Murcia (ES)
Publication Details
- Journal
- Inorganic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4qi02737j
- Citations
- 8
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 8.36
Funders
- Grantová Agentura České Republiky
- Ministerio de Ciencia e Innovación
- Agencia Estatal de Investigación