Repurposing N-acetylcysteine: Unveiling Its Potential for Memory Enhancement in Animal Model

INTRODUCTION N-acetylcysteine (NAC) is usually used as a mucolytic agent in treating chronic obstructive pulmonary disease and cystic fibrosis [1]. It is a popular antidote for paracetamol (acetaminophen) overdose, because it restores intracellular glutathione, an essential antioxidant that neutralizes toxic metabolites of paracetamol, preventing liver damage [2]. NAC is known for its extremely good protection profile, with no toxicity typically related to large doses of other drugs/ substances. The antioxidant properties of N-acetylcysteine (NAC) offer a biochemical foundation in treating diverse situations associated with oxidative stress and inflammation [3]. These properties enable NAC to combat the harmful results of reactive oxygen species (ROS) and reduce inflammatory responses, making it a promising healing agent for neurodegenerative, cardiovascular, and psychiatric disorders [4]. NAC's large therapeutic capability is supported through its capacity to modulate redox potential and inflammatory pathways, emphasizing its role in addressing pathological conditions wherein oxidative stress are potential contributing factors [5].