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Background: the perceived or anticipated stigma is associated with patients’ beliefs about the attitudes of the general public to the members of stigmatized groups. The aim of this study is to find out level of stigma and medication adherence. Methods: Descriptive cross sectional research design was performed among mental illness patient visiting on psychiatric OPD of Chitwan Medical College Teaching Hospital. A total of 106 respondents were selected by adopting Non probability Convenience sampling technique. Data was collected by using structured interview schedule. Collected data was analyzed and interpreted through descriptive inferential statistic. Results: The findings of this study revealed that highest 68.9% respondents was found having mild level of stigma where as 23.6% was found having moderate level of stigma & remaining 7.5% had minimal level of stigma perceived. Similarly lowest 92.5% respondent was found having low level of medication adherence where as 7.5% respondent was found medium level of medication adherence. There is a significant correlation between self-stigma and adherence to treatment. Conclusion: The study showed a significant correlation between self-stigma and adherence to treatment. High levels of self-stigma are associated with discontinuation of medications without a psychiatrist’s recommendation. This connection was present in all diagnostic groups.