Expression of PAX6 and Keratocyte-Characteristic Markers in Human Limbal Stromal Cells of Congenital Aniridia and Healthy Subjects, <i>In Vitro</i>
Our investigation affirms the altered expression of PAX6 and keratocyte-specific markers in AN-LSCs relative to healthy controls. Both NGSC- and LGSF-medium exerted distinct effects on both LSCs and AN-LSCs. The observed variations in PAX6 and keratocyte-specific marker expression in AN-LSCs may play a pivotal role in the development and progression of aniridia-associated keratopathy.
Authors
- Tanja Stachon (ORCID: https://orcid.org/0000-0001-7009-7125)
- Zhen Li (ORCID: https://orcid.org/0000-0001-5491-2169)
- Maryam Amini (ORCID: https://orcid.org/0009-0000-3118-9959)
- Shweta Suiwal (ORCID: https://orcid.org/0000-0002-1230-1279)
- Nóra Szentmáry (ORCID: https://orcid.org/0000-0001-8019-1481)
- Fabian Norbert Fries (ORCID: https://orcid.org/0000-0002-8526-4712)
- M. Berger (ORCID: https://orcid.org/0000-0003-2961-0251)
- Berthold Seitz (ORCID: https://orcid.org/0000-0001-9701-8204)
- Lei Shi (ORCID: https://orcid.org/0000-0001-5105-8374)
- Ning Chai (ORCID: https://orcid.org/0000-0001-9689-8887)
- Julia Zimmermann
- Simon Trusen
Institutions
- University Medical Center (US)
- University Hospital and Clinics (US)
- Anhui Provincial Hospital (CN)
- Saarland University (DE)
Publication Details
- Journal
- Current Eye Research
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1080/02713683.2025.2449915
- Citations
- 8
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.88