Targeting P21‐Activated Kinase 2 as a Novel Therapeutic Approach to Mitigate Endoplasmic Reticulum Stress in Heart Failure With Preserved Ejection Fraction
Pak2 prevents HFpEF progression, exerting cardioprotective effects against ER stress. These insights underscore the therapeutic value of Pak2 in HFpEF.
Authors
- Darren Green (ORCID: https://orcid.org/0000-0002-9370-8176)
- Susanne S. Hille (ORCID: https://orcid.org/0000-0002-9809-4636)
- Elizabeth J. Cartwright (ORCID: https://orcid.org/0000-0002-6836-7795)
- S Samman (ORCID: https://orcid.org/0000-0002-6408-6996)
- Min Zi (ORCID: https://orcid.org/0000-0002-4183-1818)
- Tayyiba Azam (ORCID: https://orcid.org/0000-0002-6099-0494)
- Yanrong Liu
- Hongyuan Zhang (ORCID: https://orcid.org/0000-0002-1012-4141)
- Oliver Josef Müller (ORCID: https://orcid.org/0000-0001-8223-2638)
- Feihu Zhou (ORCID: https://orcid.org/0000-0001-6154-013X)
- Pablo Binder (ORCID: https://orcid.org/0000-0002-5927-5928)
- Binh Nguyen (ORCID: https://orcid.org/0000-0002-5584-0379)
- Fay Pu
- Xin Wang (ORCID: https://orcid.org/0000-0001-7555-5244)
- Honglin Xu (ORCID: https://orcid.org/0000-0003-4554-862X)
Institutions
- Furness General Hospital (GB)
- University of Manchester (GB)
- Northern Health and Social Care Trust (GB)
- German Centre for Cardiovascular Research (DE)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1161/jaha.124.035302
- Citations
- 2
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.30