Impact of Simulated Gastrointestinal Fluid: Viscosity, Surface Tension, and pH on the Dissolution and Rheology Assessment of Viscosity of Two Commercial Candesartan Cilexetil Products
Higher viscosity media slow the dissolution rate of a product, where a gel layer forms on the tablet surface.The results show variation in the dissolution media. This may reveal differences in the dissolution rates of the same drug in different products and media. Considering, viscosity's effect on dissolution might improve patient outcomes when treated with different products.
Authors
- Mohammad Nafi Solaiman Al-Sabi (ORCID: https://orcid.org/0000-0003-2277-4587)
- Ola Tarawneh (ORCID: https://orcid.org/0000-0001-5876-6939)
- Rana H. Sejare
- Samah A. Ata (ORCID: https://orcid.org/0000-0003-1990-3317)
- Hadeel Abu Mahfouz (ORCID: https://orcid.org/0000-0003-3636-0334)
- Samar Bishtawi
- Rania Hamed (ORCID: https://orcid.org/0000-0001-7132-801X)
- Sameer Alkouz
Institutions
- Al-Zaytoonah University of Jordan (JO)
- Jordan University of Science and Technology (JO)
- King Faisal University (SA)
Publication Details
- Journal
- Turkish Journal of Pharmaceutical Sciences
- Published
- 2025-01-10
- DOI
- https://doi.org/10.4274/tjps.galenos.2023.35737
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00