A comprehensive multicenter analysis of clinical, molecular, and imaging characteristics and outcomes of H3 K27–altered diffuse midline glioma in adults
Adult patients with H3 K27-altered DMG showed distinct clinical, histological, and imaging characteristics compared to pediatric counterparts, with a significantly better prognosis. The authors' results suggest that aggressive surgery should be pursued when deemed feasible for better survival outcomes.
Authors
- Rajan Jain (ORCID: https://orcid.org/0000-0002-4879-0457)
- Jong Hee Chang (ORCID: https://orcid.org/0000-0003-1509-9800)
- Yae Won Park (ORCID: https://orcid.org/0000-0001-8907-5401)
- Sung Soo Ahn (ORCID: https://orcid.org/0000-0002-0503-5558)
- Sharon L. Gardner (ORCID: https://orcid.org/0000-0002-8857-5487)
- Kyunghwa Han (ORCID: https://orcid.org/0000-0002-5687-7237)
- Kaeum Choi (ORCID: https://orcid.org/0009-0006-3768-1219)
- Andrew C. McClelland
- Yongsik Sim (ORCID: https://orcid.org/0000-0003-2711-2793)
- Seung‐Koo Lee (ORCID: https://orcid.org/0000-0001-5646-4072)
- Se Hoon Kim (ORCID: https://orcid.org/0000-0001-7516-7372)
Institutions
- Yonsei University (KR)
- Samsung Medical Center (KR)
- New York University (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3171/2024.8.jns241180
- Citations
- 3
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.88