Repetitive and extensive focused ultrasound–mediated bilateral frontal blood-brain barrier opening for Alzheimer’s disease
This study confirmed the safety and efficacy of more frequent and extensive bilateral frontal BBB opening over multiple sessions in patients with AD. Furthermore, this is the first clinical trial to demonstrate improvement in neuropsychiatric symptoms through BBB opening alone, without concurrent administration of antibody medications.
Authors
- Seun Jeon (ORCID: https://orcid.org/0000-0003-2817-3352)
- Kyung Won Chang (ORCID: https://orcid.org/0000-0002-8697-1195)
- Sung Woo Kang (ORCID: https://orcid.org/0000-0001-9791-6899)
- Jin Woo Chang (ORCID: https://orcid.org/0000-0002-2717-0101)
- Byoung Seok Ye (ORCID: https://orcid.org/0000-0003-0187-8440)
Institutions
- Yonsei University (KR)
- Korea University Medical Center (KR)
- Samsung Medical Center (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3171/2024.8.jns24989
- Citations
- 9
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 12.50
Funders
- Focused Ultrasound Foundation
- Korea Health Industry Development Institute