Pachyphyllanone, a new cycloartane triterpenoid isolated from <i>Aglaia pachyphylla</i> and its cytotoxic activity
<i>Aglaia pachyphylla</i> is a species from the <i>Aglaia</i> genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (<b>1</b>), along with four known compounds (<b>2</b>-<b>5</b>) were isolated from <i>Aglaia pachyphylla</i> Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds <b>1</b>-<b>5</b> showed cytotoxic activities against MCF-7 with IC<sub>50</sub> values ranging from 160.74 to 299.75 μM.
Authors
- Kindi Farabi (ORCID: https://orcid.org/0000-0001-5552-3827)
- Hadi Kuncoro (ORCID: https://orcid.org/0000-0002-3406-522X)
- Mohamad Nurul Azmi (ORCID: https://orcid.org/0000-0002-2447-0897)
- Unang Supratman (ORCID: https://orcid.org/0000-0003-1104-2321)
- Rustaman
- Al Arofatus Naini
- Sofa Fajriah (ORCID: https://orcid.org/0000-0002-1758-2102)
- Desi Harneti (ORCID: https://orcid.org/0000-0002-8120-7892)
- Mohamad Azlan Nafiah
- Wahyu Safriansyah (ORCID: https://orcid.org/0000-0002-3243-4001)
- Endang Juliansyah
Institutions
- Universiti Sains Malaysia (MY)
- Sultan Idris Education University (MY)
- National Nuclear Energy Agency of Indonesia (ID)
- Mulawarman University (ID)
- Padjadjaran University (ID)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1080/10286020.2024.2446280
- Citations
- 2
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Universitas Padjadjaran