Selective HDAC8 inhibition by PCI-34051 attenuates inflammation and airway remodeling in asthma <i>via</i> miR-381-3p-TGFβ3 axis
In a mouse model, HDAC8 inhibitor PCI-34051 exhibits comprehensive control of asthmatic changes, including inflammation and airway remodeling.
Authors
- Delei Kong
- Shiyao Bai
- Jieyu Zhao (ORCID: https://orcid.org/0009-0003-9956-5481)
- Chenye Feng
- Xiaochun Zhang (ORCID: https://orcid.org/0000-0003-0793-9339)
- Jiamin Sun (ORCID: https://orcid.org/0000-0001-9903-0629)
- Wenyang Li (ORCID: https://orcid.org/0000-0002-2655-7144)
- Xinming Su
- Ying Pan (ORCID: https://orcid.org/0000-0002-9477-5119)
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Translational Internal Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1515/jtim-2023-0135
- Citations
- 7
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 1.64