A novel application perspective of the clinical-used drug verapamil on osteoporosis via targeting Txnip
The inhibition of Txnip by verapamil in osteoclasts and osteoblasts leads to low bone turnover and reduced bilateral ovariectomy-induced mice bone loss, which points out its great clinical translation potential on postmenopausal osteoporosis treatment.
Authors
- Kewei Rong
- Peixiang Ma (ORCID: https://orcid.org/0000-0001-6794-1663)
- Lei Cui (ORCID: https://orcid.org/0000-0002-9052-6094)
- Yinghua Li (ORCID: https://orcid.org/0000-0003-2058-1191)
- An Qin (ORCID: https://orcid.org/0000-0002-8785-8848)
- Xiankun Cao (ORCID: https://orcid.org/0000-0003-1993-8181)
- Pu Zhang
- Hang Zhang (ORCID: https://orcid.org/0000-0002-4851-3492)
- Kexin Liu (ORCID: https://orcid.org/0000-0002-0699-8452)
- Xiaofei Cheng (ORCID: https://orcid.org/0000-0001-9307-660X)
- Xiao Yang
- Qi Hua (ORCID: https://orcid.org/0000-0003-1382-3009)
- Jie Zhao (ORCID: https://orcid.org/0000-0001-5687-9286)
- Shaotian Fu
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- Fudan University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jot.2024.10.006
- Citations
- 3
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.14