FASN inhibition shows the potential for enhancing radiotherapy outcomes by targeting glycolysis, AKT, and ERK pathways in breast cancer
FASN knockdown disrupts fatty acid synthesis and glycolysis, inhibits cell proliferation and induces apoptosis. The increased radiosensitivity after FASN inhibition suggests that it could potentially complement radiotherapy in treating breast cancer.
Authors
- Deng-Yu Kuo
- Ching-I Chen (ORCID: https://orcid.org/0000-0002-3563-6776)
- Hui-Yen Chuang
Institutions
- National Yang Ming Chiao Tung University (TW)
- Chang Gung Memorial Hospital (TW)
- Far Eastern Memorial Hospital (TW)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1080/09553002.2024.2446585
- Citations
- 3
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Yen Tjing Ling Medical Foundation