Dengue severity by serotype and immune status in 19 years of pediatric clinical studies in Nicaragua
These findings demonstrate differences in dengue severity by serotype and immune status and emphasize the critical need for a dengue vaccine with balanced effectiveness against all four serotypes, particularly as existing vaccines show variable efficacy by serotype and serostatus.
Authors
- Guillermina Kuan (ORCID: https://orcid.org/0000-0002-5251-173X)
- Ángel Balmaseda (ORCID: https://orcid.org/0009-0006-3812-5978)
- Miguel Plazaola (ORCID: https://orcid.org/0000-0002-4153-2615)
- Sonia Arguello (ORCID: https://orcid.org/0009-0005-0915-5273)
- José Víctor Zambrana (ORCID: https://orcid.org/0000-0003-0107-6173)
- Federico Narvaez (ORCID: https://orcid.org/0000-0001-8529-3102)
- Nery Sánchez (ORCID: https://orcid.org/0000-0002-0070-3895)
- Carlos Eduardo Lucena Montenegro (ORCID: https://orcid.org/0000-0002-7330-7674)
- Gabriela Paz Bailey
- Elsa Videa
- José G. Juárez (ORCID: https://orcid.org/0000-0002-0583-478X)
- Karla González (ORCID: https://orcid.org/0009-0001-4881-5802)
- Sergio Ojeda (ORCID: https://orcid.org/0000-0003-2512-2306)
- Daniel Camprubí-Ferrer
- Eva Harris
- Fanny Barrios
Institutions
- University of Michigan (US)
- Michigan United (US)
- National Center for Emerging and Zoonotic Infectious Diseases (US)
- Ministerio de Salud (NI)
- Hospital Infantil Manuel de Jesús Rivera (NI)
- Sustainable Sciences Institute (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1371/journal.pntd.0012811
- Citations
- 15
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 28.18
Funders
- Bill and Melinda Gates Foundation
- International AIDS Vaccine Initiative
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases