Airway MMP-12 and DNA methylation in COPD: an integrative approach
Our findings indicate that airway MMP-12 may partially be regulated by epigenetic mechanisms and that this regulation is disrupted in COPD. Furthermore, integration with COPD GWAS data suggests that this dysregulation is influenced by a combination of environmental factors, disease processes, and genetics, with the latter potentially playing a lesser role.
Authors
- Annelie Behndig (ORCID: https://orcid.org/0000-0002-1533-9002)
- Anne Lindberg (ORCID: https://orcid.org/0000-0002-3292-7471)
- Robert Linder (ORCID: https://orcid.org/0000-0003-4266-1782)
- Erik Melén (ORCID: https://orcid.org/0000-0002-8248-0663)
- Jonas Eriksson Ström (ORCID: https://orcid.org/0000-0002-3434-988X)
- Simon Kebede Merid (ORCID: https://orcid.org/0000-0001-5974-7676)
- Jamshid Pourazar (ORCID: https://orcid.org/0000-0003-0041-4644)
Institutions
- Karolinska Institutet (SE)
- Sachs' Children and Youth Hospital (SE)
- Umeå University (SE)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1186/s12931-024-03088-3
- Citations
- 6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- Hjärt-Lungfonden
- Vetenskapsrådet
- Science for Life Laboratory