Exploration and computational assessment of ochrocephalamine G from <i>Oxytropis ochrocephala</i> as an anti-HBV candidate
Three compounds, including a novel quinolizidine alkaloid, ochrocephalamine G (<b>1</b>), were isolated from <i>Oxytropis ochrocephala</i>. Structural elucidation was achieved through spectroscopic analysis and electronic circular dichroism. Biological assays showed that ochrocephalamine G (100 μM) inhibited HBsAg and HBeAg by 8.28% and 16.17%, respectively. Computational studies, including molecular docking and dynamics simulations, revealed its binding mode with HBV core protein, providing a solid foundation for developing <i>O. ochrocephala</i> as an anti-HBV therapeutic agent.
Authors
- Jianbo Tong (ORCID: https://orcid.org/0000-0001-5536-2701)
- Yan‐Rong Zeng (ORCID: https://orcid.org/0009-0004-4859-2241)
- Cheng‐Jian Tan (ORCID: https://orcid.org/0000-0001-6381-9599)
- Yakun Zhang (ORCID: https://orcid.org/0000-0002-9636-8576)
- Min Yang (ORCID: https://orcid.org/0000-0002-9034-3175)
- Xue Zhan (ORCID: https://orcid.org/0000-0003-0529-0417)
- Jing Tan (ORCID: https://orcid.org/0000-0002-8004-9909)
Institutions
- Guizhou University (CN)
- Guizhou Minzu University (CN)
- Shaanxi University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1080/10286020.2024.2441773
- Citations
- 1
- Primary Topic
- Plant Pathogenic Bacteria Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China