Ubiquitination of TFEB increased intestinal permeability to aggravate metabolic dysfunction–associated steatohepatitis
The ubiquitination of TFEB plays a pivotal role in increasing intestinal permeability and promoting the progression of MASH by inhibiting autophagy. Intestinal TFEB may represent a novel therapeutic target for the treatment of MASH.
Authors
- Liang Peng (ORCID: https://orcid.org/0000-0001-8377-0833)
- Zai Wang (ORCID: https://orcid.org/0000-0002-8548-1362)
- Zecheng Li (ORCID: https://orcid.org/0000-0003-4200-0941)
- Lang Chen (ORCID: https://orcid.org/0000-0001-7032-2513)
- Lihong Liu (ORCID: https://orcid.org/0000-0003-4817-3173)
- Donghai Liu (ORCID: https://orcid.org/0000-0002-5610-2183)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1097/hep.0000000000001214
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35