Rnd3 Ameliorates Diabetic Cardiac Microvascular Injury via Facilitating Trim40-Mediated Rock1 Ubiquitination
Impaired cardiac microvascular function is a significant contributor to diabetic cardiomyopathy. Rnd3 expression is notably downregulated in cardiac microvascular endothelial cells under diabetic conditions. Rnd3 overexpression mitigates diabetic myocardial microvascular injury and improves cardiac function through the Rock1/myosin light chain signaling pathway. Rnd3 facilitates the recruitment and interaction with Trim40 to promote Rock1 ubiquitination, thereby preserving endothelial barrier integrity in the diabetic heart.
Authors
- Mengyuan Jiang
- Xinchun Dai
- Jiye Zhang (ORCID: https://orcid.org/0000-0001-9359-6701)
- Xiao Zhang (ORCID: https://orcid.org/0000-0002-3894-8513)
- Xuebin Zhang (ORCID: https://orcid.org/0000-0001-7400-0351)
- Xiaohua Zhang (ORCID: https://orcid.org/0009-0002-1707-6346)
- Jie Lin
- Yan Zhang (ORCID: https://orcid.org/0000-0001-5395-4527)
- Dongdong Sun (ORCID: https://orcid.org/0000-0003-2147-3977)
- Yu Duan (ORCID: https://orcid.org/0009-0003-0604-3570)
- Ge Wen (ORCID: https://orcid.org/0000-0003-2114-9157)
- Hai Qiang
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Diabetes
- Published
- 2025-01-10
- DOI
- https://doi.org/10.2337/db24-0543
- Citations
- 3
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 4.16