Appearance of green tea compounds in plasma following acute green tea consumption is modulated by the gut microbiome in mice

Foods contain thousands of unique and biologically important compounds beyond the macro- and micro-nutrients listed on nutrition facts labels. In mammals, many of these compounds are metabolized or co-metabolized by the community of microbes in the colon. These microbes may impact the thousands of biologically important compounds we consume; therefore, understanding microbial metabolism of food compounds will be important for understanding how foods impact health. We used metabolomics to track green tea compounds in plasma of mice with and without complex microbiomes. From this, we can start to recognize certain groups of green tea-derived compounds that are impacted by mammalian microbiomes. This research presents a novel technique for understanding microbial metabolism of food-derived compounds in the gut, which can be applied to other foods.

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Publication Details

Journal
Microbiology Spectrum
Published
2025-01-10
DOI
https://doi.org/10.1128/spectrum.01799-24
Citations
2
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.81

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article

Appearance of green tea compounds in plasma following acute green tea consumption is modulated by the gut microbiome in mice

Katrina Doenges, Harry Smith, Nichole Reisdorph, Kristine A. Kuhn et al.
2 citations
Microbiology Spectrum
Gut microbiota and health
0.81
article

Appearance of green tea compounds in plasma following acute green tea consumption is modulated by the gut microbiome in mice

Katrina Doenges, Harry Smith, Nichole Reisdorph, Kristine A. Kuhn, Nichole Nusbacher, John Sterrett, Laura M. Saba, Cassandra L. Levens, Catherine Lozupone, Mike L. Armstrong, Richard M. Reisdorph, Kevin D. Quinn
article en
2 citations

Abstract

Foods contain thousands of unique and biologically important compounds beyond the macro- and micro-nutrients listed on nutrition facts labels. In mammals, many of these compounds are metabolized or co-metabolized by the community of microbes in the colon. These microbes may impact the thousands of biologically important compounds we consume; therefore, understanding microbial metabolism of food compounds will be important for understanding how foods impact health. We used metabolomics to track green tea compounds in plasma of mice with and without complex microbiomes. From this, we can start to recognize certain groups of green tea-derived compounds that are impacted by mammalian microbiomes. This research presents a novel technique for understanding microbial metabolism of food-derived compounds in the gut, which can be applied to other foods.

Microbiology SpectrumVol. 13(2)
University of Colorado Boulder (US), Quantitative BioSciences (US), Center for Rheumatology (US), University of Colorado Anschutz Medical Campus (US), University of Colorado Denver (US)
National Science Foundation, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences
Zero hunger
Openalex Percentile: Top 32%
Gut microbiota and health
0.81
DOIOpen Access PDFOpenAlex
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