Genetic predisposition to high circulating levels of interleukin 6 and risk for Alzheimer's disease. Discovery and replication
Genetic predisposition to higher circulating levels of IL-6 was associated with an increased risk for AD, supporting the role of IL-6-related pathways in AD pathogenesis, and suggesting that genetic predisposition to proinflammatory states might trigger or accelerate AD-related neuropathology.
Authors
- Jean‐Charles Lambert (ORCID: https://orcid.org/0000-0003-0829-7817)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Matthew R. Scott (ORCID: https://orcid.org/0000-0003-1404-4437)
- Efthimios Dardiotis (ORCID: https://orcid.org/0000-0003-2957-641X)
- Niki Mourtzi (ORCID: https://orcid.org/0000-0002-8650-4239)
- Alexandros Hatzimanolis (ORCID: https://orcid.org/0000-0002-0291-1399)
- Alfredo Ramı́rez (ORCID: https://orcid.org/0000-0003-4991-763X)
- Paraskevi Sakka (ORCID: https://orcid.org/0000-0003-4195-492X)
- Qiong Yang (ORCID: https://orcid.org/0000-0002-2442-2094)
- Eva Ntanasi (ORCID: https://orcid.org/0000-0001-9311-0994)
- Mary Yannakoulia (ORCID: https://orcid.org/0000-0003-2171-7337)
- Marios K. Georgakis (ORCID: https://orcid.org/0000-0003-3507-3659)
- Mary H. Kosmidis (ORCID: https://orcid.org/0000-0001-8790-1220)
- Alexa S. Beiser (ORCID: https://orcid.org/0000-0001-8551-7778)
- Eirini Mamalaki (ORCID: https://orcid.org/0000-0002-5714-3032)
- Georgios Hadjigeorgiou (ORCID: https://orcid.org/0000-0003-4002-2776)
- Sokratis Charisis (ORCID: https://orcid.org/0000-0001-6578-393X)
- Nikolaos Scarmeas
- Claudia L. Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
Institutions
- Broad Institute (US)
- Boston University (US)
- University of Thessaly (GR)
- Inserm (FR)
- National and Kapodistrian University of Athens (GR)
- Aristotle University of Thessaloniki (GR)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- German Center for Neurodegenerative Diseases (DE)
- Centre Hospitalier Universitaire de Lille (FR)
- Harokopio University of Athens (GR)
- University of Cyprus (CY)
- University Hospital of Larissa (GR)
- Institute for Neurodegenerative Disorders (US)
- Eginition Hospital (GR)
- Greek Association of Alzheimer's Disease and Related Disorders (GR)
- Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.tjpad.2024.100018
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- Alzheimer's Association
- Ministry of Health and Social Solidarity, Greece