Informing etiological heterogeneity of mild cognitive impairment and risk for progression to dementia with plasma p-tau217
MCI is etiologically heterogeneous. The presence of Alzheimer's pathology defined by elevated plasma p-tau217 in individuals with MCI significantly worsens prognosis. Neuropsychiatric symptoms may contribute to cognitive complaints and risk for progressive decline irrespective of AD pathology. Plasma p-tau217 can inform our understanding of base rates of different MCI phenotypes on a larger scale. As with other AD biomarkers, frequency of elevated plasma p-tau217 and odds of progression to dementia requires careful consideration of recruitment source (clinic- vs. community-based), especially across ethno-racially diverse older adults. Ongoing integration of emerging neurodegenerative disease biomarkers with detailed clinical evaluations will continue to improve treatment specificity and prognosis.
Authors
- Franchesca Arias (ORCID: https://orcid.org/0000-0002-5448-6849)
- Warren Barker (ORCID: https://orcid.org/0000-0003-2171-7142)
- Breton M. Asken
- David E. Vaillancourt (ORCID: https://orcid.org/0000-0002-5663-6476)
- Rosie E. Curiel (ORCID: https://orcid.org/0000-0001-6505-7030)
- Idaly Vélez Uribe
- Melissa J. Armstrong (ORCID: https://orcid.org/0000-0002-2163-1907)
- Emily F. Matusz (ORCID: https://orcid.org/0000-0002-8255-0641)
- Mónica Rosselli (ORCID: https://orcid.org/0000-0003-2656-9505)
- Michael Marsiske (ORCID: https://orcid.org/0000-0001-5973-2116)
- Wei‐en Wang (ORCID: https://orcid.org/0000-0001-8555-9062)
- Shellie‐Anne Levy (ORCID: https://orcid.org/0000-0001-5939-2887)
- Jesse C. DeSimone (ORCID: https://orcid.org/0000-0002-3823-8765)
- Elizabeth Crocco (ORCID: https://orcid.org/0000-0002-0917-386X)
- Glenn E. Smith (ORCID: https://orcid.org/0000-0003-1506-9484)
- Jacob Fiala (ORCID: https://orcid.org/0000-0002-0430-869X)
- David Loewenstein (ORCID: https://orcid.org/0000-0001-6788-2798)
- Steven T. DeKosky (ORCID: https://orcid.org/0000-0003-3743-2758)
- Ranjan Duara (ORCID: https://orcid.org/0000-0001-8060-6309)
Institutions
- University of Miami (US)
- Atlantic University (US)
- University of Florida Health (US)
- University of Florida (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Florida Atlantic University (US)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.tjpad.2024.100011
- Citations
- 9
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 13.24
Funders
- Biogen
- National Institutes of Health
- National Institute on Aging