Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease
GSDME is involved in DED pathogenesis by mediating inflammation via the pyroptosis pathway, GSDME inhibition may be a therapeutic target for DED.
Authors
- Xiaoyong Yuan (ORCID: https://orcid.org/0000-0003-0782-4187)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-9486-9388)
- Ling Wang (ORCID: https://orcid.org/0000-0003-3220-6065)
- Xia Hua (ORCID: https://orcid.org/0000-0001-5481-2838)
- Ye Tian (ORCID: https://orcid.org/0009-0000-2586-7901)
- Yongxiao Dong
Institutions
- Xian Yang Central Hospital (CN)
- Tianjin Medical University Eye Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1167/iovs.66.1.24
- Citations
- 5
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City