Anion Transport by Bambusuril‐Bile Acid Conjugates: Drastic Effect of the Cholesterol Content
Abstract Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self‐assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well‐established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.
Authors
- Vladimír Šindelář (ORCID: https://orcid.org/0000-0003-0090-5961)
- Matúš Chvojka (ORCID: https://orcid.org/0000-0002-3485-6064)
- Pia Jurček (ORCID: https://orcid.org/0000-0003-4372-9187)
- Huaqiang Zeng (ORCID: https://orcid.org/0000-0002-8246-2000)
- Hennie Valkenier (ORCID: https://orcid.org/0000-0002-4409-0154)
- Jacopo Torrisi (ORCID: https://orcid.org/0009-0009-9082-3476)
- Xinxin Zhang (ORCID: https://orcid.org/0000-0002-6229-0029)
Institutions
- Université Libre de Bruxelles (BE)
- Masaryk University (CZ)
- Theodore Roosevelt High School (US)
- RECETOX (CZ)
- Fuzhou University (CN)
Publication Details
- Journal
- Angewandte Chemie
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1002/ange.202424754
- Citations
- 2
- Primary Topic
- Polysaccharides Composition and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- European Commission
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Grantová Agentura České Republiky
- Fonds De La Recherche Scientifique - FNRS
- Masarykova Univerzita
- RECETOX Přírodovědecké Fakulty Masarykovy Univerzity