LOX-induced tubulointerstitial fibrosis via the TGF-β/LOX/Snail axis in diabetic mice
Hyperglycemia induces partial EMT of RTECs via the TGF-β/LOX/Snail axis, thereby contributing to diabetic kidney fibrosis. Inhibiting LOX can effectively reverse the partial EMT of RTECs, diminish diabetic kidney fibrosis, and improve renal function.
Authors
- Heyangzi Li
- Mohan Chen (ORCID: https://orcid.org/0000-0002-8071-5633)
- Xiaoming Zhang (ORCID: https://orcid.org/0000-0001-5567-6786)
- Yicheng Lin
- Yicheng Lu
Institutions
- Tongji University (CN)
- Central South University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s12967-024-06056-z
- Citations
- 9
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- Zhejiang University
- National College Students Innovation and Entrepreneurship Training Program
- Zhejiang Xinmiao Talents Program