miR-9-5p/HMMR regulates the tumorigenesis and progression of clear cell renal cell carcinoma through EMT and JAK1/STAT1 signaling pathway
HMMR is overexpressed in ccRCC, and there is a significant link between high HMMR expression and tumor progression, as well as poor patient prognosis. Specifically, HMMR could be targeted and inhibited by miR-9-5p and might modulate the tumorigenesis and progression of ccRCC through both EMT and JAK1/STAT1 signaling pathway.
Authors
- Weitao Zhan
- Xinyang Niu
- Xueyou Ma (ORCID: https://orcid.org/0000-0002-8146-8611)
- Dingheng Lu
- Shan Huang (ORCID: https://orcid.org/0000-0002-4448-7725)
- Yuchen Shi (ORCID: https://orcid.org/0000-0002-8904-9884)
- Xiaoyan Liu (ORCID: https://orcid.org/0000-0002-1732-5923)
- Ben Liu (ORCID: https://orcid.org/0000-0002-0709-6784)
- Yuxiao Li (ORCID: https://orcid.org/0000-0002-2042-7787)
- Jiazhu Sun
- Kai Yu
Institutions
- Zhejiang Cancer Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s12967-024-05988-w
- Citations
- 8
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 12.15
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Medical and Health Research Project of Zhejiang Province