Anion Transport by Bambusuril‐Bile Acid Conjugates: Drastic Effect of the Cholesterol Content
Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.
Authors
- Vladimír Šindelář (ORCID: https://orcid.org/0000-0003-0090-5961)
- Matúš Chvojka (ORCID: https://orcid.org/0000-0002-3485-6064)
- Pia Jurček (ORCID: https://orcid.org/0000-0003-4372-9187)
- Huaqiang Zeng (ORCID: https://orcid.org/0000-0002-8246-2000)
- Hennie Valkenier (ORCID: https://orcid.org/0000-0002-4409-0154)
- Jacopo Torrisi (ORCID: https://orcid.org/0009-0009-9082-3476)
- Xinxin Zhang (ORCID: https://orcid.org/0000-0002-6229-0029)
Institutions
- Université Libre de Bruxelles (BE)
- Masaryk University (CZ)
- Theodore Roosevelt High School (US)
- RECETOX (CZ)
- Fuzhou University (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1002/anie.202424754
- Citations
- 6
- Primary Topic
- Molecular Sensors and Ion Detection
- Type
- article
- Field-Weighted Citation Impact
- 4.54
Funders
- European Commission
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Grantová Agentura České Republiky
- Fonds De La Recherche Scientifique - FNRS
- Masarykova Univerzita
- RECETOX Přírodovědecké Fakulty Masarykovy Univerzity