A plug-and-play system for polycyclic tetramate macrolactam production and functionalization
By employing our plug-and-play system for PoTeMs, we reconstructed the ikarugamycin biosynthesis and generated five derivatives of ikarugamycin. This platform will generally facilitate the investigation of new PoTeM biosynthetic cyclization and tailoring reactions in the future.
Authors
- Sebastian Schuler
- Manuel Einsiedler (ORCID: https://orcid.org/0000-0001-5275-3758)
- Tobias A. M. Gulder (ORCID: https://orcid.org/0000-0001-6013-3161)
- Anna Glöckle
Institutions
- Helmholtz Centre for Infection Research (DE)
- Helmholtz Institute for Pharmaceutical Research Saarland (DE)
- Technische Universität Dresden (DE)
- Saarland University (DE)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1186/s12934-024-02630-8
- Citations
- 6
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Technische Universität Dresden