PROTAC-Mediated GSPT1 Degradation Impairs the Expression of Fusion Genes in Acute Myeloid Leukemia
These findings suggest a new role of GSPT1 in regulating leukemic transcriptional networks and open a new therapeutic strategy to target leukemic fusion genes in pediatric AML patients.
Authors
- C. Michel Zwaan (ORCID: https://orcid.org/0000-0001-6892-8268)
- Alicia Perzolli (ORCID: https://orcid.org/0000-0003-1302-0943)
- Jan Krönke (ORCID: https://orcid.org/0000-0002-4649-0506)
- Michael Gütschow (ORCID: https://orcid.org/0000-0002-9376-7897)
- Olaf T Heidenreich (ORCID: https://orcid.org/0000-0001-5404-6483)
- Christian Steinebach (ORCID: https://orcid.org/0000-0001-5638-1955)
- Farnaz Barneh (ORCID: https://orcid.org/0000-0003-4715-9732)
Institutions
- University of Bonn (DE)
- University Medical Center Utrecht (NL)
- Princess Máxima Center (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- University Hospital Ulm (DE)
- Newcastle University (GB)
Publication Details
- Journal
- Cancers
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3390/cancers17020211
- Citations
- 3
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Sanofi
- BeiGene
- Syndax Pharmaceuticals
- Stichting Kinderen Kankervrij
- Servier