Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status?

SSIIi levels were significantly lower in patients with migraine with aura (MA), compared to MO. MA showed a greater, though non-significant, decrease between the two measurements compared to those with migraine without aura (MO) and outpatient controls, whose SSIIi levels remained consistently higher. The control group displayed similar findings to MO inpatients, suggesting persistent systemic inflammation in a subset of migraine patients regardless of in patient or outpatient of presentation and highlighting the need for future studies to more rigorously evaluate the role of systemic inflammation in migraine pathophysiology, chronicity, and progression though the multiple phases of migraine including the interictal phase.

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Publication Details

Journal
The Journal of Headache and Pain
Published
2025-01-10
DOI
https://doi.org/10.1186/s10194-024-01929-6
Citations
15
Primary Topic
Migraine and Headache Studies
Type
article
Field-Weighted Citation Impact
22.07
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article

Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status?

Sheila G. Crewther, Paolo Martelletti, Nina Riddell, Tissa Wijeratne et al.
15 citations
The Journal of Headache and Pain
Migraine and Headache Studies
22.07
article

Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status?

Sheila G. Crewther, Paolo Martelletti, Nina Riddell, Tissa Wijeratne, Vasso Apostolopoulos, Leila Karimi, Carmela Sales, Melanie Murphy, Chanith Wijeratne
article en
15 citations

Abstract

SSIIi levels were significantly lower in patients with migraine with aura (MA), compared to MO. MA showed a greater, though non-significant, decrease between the two measurements compared to those with migraine without aura (MO) and outpatient controls, whose SSIIi levels remained consistently higher. The control group displayed similar findings to MO inpatients, suggesting persistent systemic inflammation in a subset of migraine patients regardless of in patient or outpatient of presentation and highlighting the need for future studies to more rigorously evaluate the role of systemic inflammation in migraine pathophysiology, chronicity, and progression though the multiple phases of migraine including the interictal phase.

The Journal of Headache and PainVol. 26(1)
La Trobe University (AU), Caucasus University (GE), Monash Medical Centre (AU), Speech Pathology Australia (AU), Myer Foundation (AU), Australian Hearing (AU), Western Health (AU), Australian Institute for Musculoskeletal Science (AU), Sunshine Hospital (AU), Unitelma Sapienza University (IT), Victoria University (AU), RMIT University (AU), Sapienza University of Rome (IT)
Openalex Percentile: Top 0%
Migraine and Headache Studies
22.07
DOIOpen Access PDFOpenAlex
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Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status? — Sheila G. Crewther, Paolo Martelletti, et al. · The Journal of Headache and Pain (2025) | TGRS Research Map | TGRS