Cancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer
This study demonstrated that H1975 cells stimulated by almonertinib promoted the accumulation of CAFs in NSCLC cells, likely through increased secretion of TGF-β1. The accumulation of CAFs enhanced the survival of NSCLC cells undergoing almonertinib treatment and induced drug resistance. Additionally, the mechanism underlying CAF-induced drug resistance in NSCLC cells was potentially linked to the activation of the YAP/TAZ signaling pathway.
Authors
- Wenzheng Zhou (ORCID: https://orcid.org/0000-0001-7148-1989)
- Huihui Zhao (ORCID: https://orcid.org/0000-0002-1768-3835)
- Yu Nie (ORCID: https://orcid.org/0000-0002-8744-0046)
- Fangfang Chen (ORCID: https://orcid.org/0000-0003-2746-2603)
- Min Sun (ORCID: https://orcid.org/0000-0002-7049-5526)
- Chuandong Zhu (ORCID: https://orcid.org/0000-0002-9986-6319)
- Guohao Wei
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1186/s12967-024-06064-z
- Citations
- 6
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 6.91
Funders
- Government of Jiangsu Province
- Nanjing University of Chinese Medicine
- Nanjing University
- Wu Jieping Medical Foundation