Targeting Pancreatic Cancer Cell Stemness by Blocking Fibronectin-Binding Integrins on Cancer-Associated Fibroblasts
Simultaneous targeting of two integrins that function as receptors for FN, a protumor ECM protein, can prevent fibroblasts from supporting the malignant behavior of pancreatic cancer cells.
Authors
- Sara M. Weis (ORCID: https://orcid.org/0009-0008-3137-4239)
- Qinlin Jiang (ORCID: https://orcid.org/0009-0008-4254-9006)
- Tami Von Schalscha (ORCID: https://orcid.org/0009-0007-8348-6200)
- Hiromi I. Wettersten (ORCID: https://orcid.org/0000-0001-7144-3122)
- Ryan M. Shepard (ORCID: https://orcid.org/0000-0002-7488-369X)
- Chengsheng Wu (ORCID: https://orcid.org/0009-0003-3091-1606)
- David A. Cheresh (ORCID: https://orcid.org/0000-0002-7193-8595)
- Chen Qian (ORCID: https://orcid.org/0009-0007-6386-9706)
- Stephen J. McCormack
- Diva Sansanwal
Institutions
- University of California San Diego (US)
- Sanford Consortium for Regenerative Medicine (US)
- BetaStem Therapeutics (United States) (US)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0491
- Citations
- 6
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 9.73
Funders
- Tobacco-Related Disease Research Program
- National Institutes of Health
- University of California, San Diego