Impaired cerebral microvascular reactivity and endothelial SK channel activity in a streptozotocin-treated mouse model of Alzheimer's disease
STZ-AD mice exhibited impaired microvascular relaxation responses to endothelium-dependent vasodilators; SK/IK channel dysfunction may be involved in the mechanism of this impairment. Acute treatment with Aβ produced dysregulated cerebrovascular endothelial SK/IK channels. Further elucidation of the role of microvascular dysfunction in AD is needed to prevent the chronic ischemia-type injury that contributes to cognitive decline.
Authors
- Frank W. Sellke (ORCID: https://orcid.org/0000-0002-8886-801X)
- Suzanne M. de la Monte (ORCID: https://orcid.org/0000-0001-5886-2306)
- Mark Broadwin (ORCID: https://orcid.org/0000-0002-0393-9983)
- Dwight D. Harris (ORCID: https://orcid.org/0000-0001-8289-2740)
- Andrew J. Sauer (ORCID: https://orcid.org/0000-0002-9268-2795)
- Hang Xing (ORCID: https://orcid.org/0000-0002-5634-1037)
- Shawn Kant (ORCID: https://orcid.org/0000-0003-4961-9691)
- Elizabeth O. Harrington (ORCID: https://orcid.org/0000-0002-3207-5301)
- Amy Princiotto
- Christopher Stone (ORCID: https://orcid.org/0000-0002-7842-8029)
- Jun Feng (ORCID: https://orcid.org/0000-0003-4762-7532)
- Meghamsh Kanuparthy (ORCID: https://orcid.org/0009-0005-7581-0555)
- Zhi‐Qi Zhang (ORCID: https://orcid.org/0000-0001-5909-0408)
- Jiayu Hu (ORCID: https://orcid.org/0000-0003-2423-9465)
- Elena Pearson
Institutions
- Providence College (US)
- Brown University (US)
- Rhode Island Hospital (US)
- Providence VA Medical Center (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1177/13872877241309120
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Institutes of Health
- National Institute of General Medical Sciences