Thioxanthone Synthesis from Thioureas through Double Aryne Insertion into a Carbon-Sulfur Double Bond
Thioxanthone synthesis from <i>o</i>-silylaryl triflates and thioureas is disclosed. Double aryne insertion into the C═S double bond of thioureas and subsequent hydrolysis realized the facile preparation of thioxanthones. A simple reaction procedure and good accessibility of <i>o</i>-silylaryl triflates allowed us to synthesize a wide range of highly functionalized thioxanthones.
Authors
- Mikio Kawada
- Suguru Yoshida (ORCID: https://orcid.org/0000-0001-5888-9330)
- Yusuke Hoshi (ORCID: https://orcid.org/0000-0001-6558-6581)
- Shinya Tabata
Institutions
- Tokyo University of Science (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1021/acs.orglett.4c04490
- Citations
- 3
- Primary Topic
- Cyclization and Aryne Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Tokuyama Science Foundation
- Japan Society for the Promotion of Science