<scp>TDP‐43</scp> Cryptic <scp>RNAs</scp> in Perry Syndrome: Differences across Brain Regions and <scp>TDP‐43</scp> Proteinopathies
We detected TDP-43 cryptic RNAs and protein in PS caudate nucleus. Given the importance of cryptic exon biology in the development of biomarkers, and the identification of novel targets for therapeutic intervention, it is imperative we understand the consequences of TDP-43 dysfunction across different brain regions and determine the targets that are specific and common to TDP-43 proteinopathies. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Monica Castanedes‐Casey (ORCID: https://orcid.org/0000-0002-8441-7801)
- Anusha Narayan
- Mark E. Reeves (ORCID: https://orcid.org/0009-0001-1091-0177)
- Keith A. Josephs (ORCID: https://orcid.org/0000-0003-2930-8634)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Mercedes Prudencio (ORCID: https://orcid.org/0000-0002-4894-4858)
- Catalina Cerquera‐Cleves (ORCID: https://orcid.org/0000-0002-3874-0261)
- Zbigniew K. Wszołek (ORCID: https://orcid.org/0000-0001-5487-1053)
- Michael DeTure (ORCID: https://orcid.org/0000-0002-4363-1262)
- Lillian M. Daughrity (ORCID: https://orcid.org/0000-0003-4644-7265)
- Virginia Estades Ayuso
- Bailey Rawlinson
- Jarosław Dulski (ORCID: https://orcid.org/0000-0002-5517-9875)
- Judy H. Dunmore
- Leonard Petrucelli (ORCID: https://orcid.org/0000-0003-2959-129X)
- Jimei Tong
- Sarah Pickles (ORCID: https://orcid.org/0000-0001-7956-4586)
- Paula Castellanos Otero
- Jesús González Bejarano (ORCID: https://orcid.org/0009-0006-1677-2760)
- Yong‐Jie Zhang (ORCID: https://orcid.org/0000-0002-9900-4313)
- Yuping Song (ORCID: https://orcid.org/0000-0001-9700-9113)
- Mei Yue
- Candela Maroto Cidfuentes
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- WinnMed (US)
- Copernicus Memorial Hospital (PL)
- Mayo Clinic in Florida (US)
- Hospital Universitario San Ignacio (CO)
- Université Laval (CA)
- Gdańsk Medical University (PL)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1002/mds.30104
- Citations
- 8
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 11.11
Funders
- BrightFocus Foundation
- Johns Hopkins University
- Target ALS
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke
- Robert Packard Center for ALS Research, Johns Hopkins University