Association Between Childhood Trauma and Anhedonia-Related Symptoms: The Mediation Role of Trait Anhedonia and Circulating Proteins
Anhedonic traits and plasma TNR5 protein levels serially mediated the association between childhood emotional neglect and anhedonia-related symptoms. The study highlights the importance of considering both psychopathological traits and biological correlates when investigating the association between childhood trauma and psychopathological symptoms.
Authors
- Yoojin Song (ORCID: https://orcid.org/0000-0002-0594-7346)
- Yeongshin Kim (ORCID: https://orcid.org/0009-0008-4925-194X)
- Yong Min Ahn (ORCID: https://orcid.org/0000-0002-4458-797X)
- Dongyoon Shin (ORCID: https://orcid.org/0000-0002-5493-5026)
- Sungwon Roh (ORCID: https://orcid.org/0000-0003-4557-3542)
- Sang Jin Rhee (ORCID: https://orcid.org/0000-0001-6221-5953)
- Kyu Young Lee (ORCID: https://orcid.org/0000-0003-3214-6082)
- Daun Shin (ORCID: https://orcid.org/0000-0002-0953-6245)
- Eun-Jeong Joo (ORCID: https://orcid.org/0000-0001-8766-8713)
- Minji Bang (ORCID: https://orcid.org/0000-0002-1669-4014)
- Hye-Young Kim (ORCID: https://orcid.org/0000-0002-2313-8892)
- Youngsoo Kim (ORCID: https://orcid.org/0000-0001-8881-0662)
- Sang‐Hyuk Lee (ORCID: https://orcid.org/0000-0001-9097-261X)
- Jihyeon Lee (ORCID: https://orcid.org/0000-0001-9744-8968)
- Hee Yeon Jung (ORCID: https://orcid.org/0000-0002-0578-2211)
Institutions
- Seoul National University (KR)
- Korea University (KR)
- Eulji University (KR)
- Seoul Metropolitan Government (KR)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Kangwon National University Hospital (KR)
- Daejeon Eulji Medical Center, Eulji University (KR)
- CHA University Bundang Medical Center (KR)
- Hanyang University Seoul Hospital (KR)
- CHA University (KR)
- Inha University Hospital (KR)
Publication Details
- Journal
- Journal of Korean Medical Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3346/jkms.2025.40.e66
- Citations
- 3
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- National Research Foundation
- Ministry of Trade, Industry and Energy
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Otsuka Pharmaceutical
- Ministry of Science and ICT, South Korea