Early adversity and inflammation at midlife: the moderating role of internalizing psychopathology
We discuss the possibility that adult internalizing symptoms and trait neuroticism together may signal the presence of temporally stable vulnerabilities that amplify the impact of childhood adversity on midlife immune alterations. The study highlights the importance of identifying emotional distress in individuals who have experienced childhood adversity to address long-term immune outcomes and enhance overall health.
Authors
- Craig A. Marquardt (ORCID: https://orcid.org/0000-0003-2714-6168)
- Noah C. Venables (ORCID: https://orcid.org/0000-0003-4916-2724)
- Paul A. Arbisi (ORCID: https://orcid.org/0000-0002-8653-9255)
- Robert F. Krueger (ORCID: https://orcid.org/0000-0001-9127-5509)
- Zachary S. Michal (ORCID: https://orcid.org/0000-0002-2372-9465)
Institutions
- University of Minnesota (US)
- Twin Cities Orthopedics (US)
- Minneapolis VA Health Care System (US)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1017/s0033291724002265
- Citations
- 2
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- U.S. Department of Veterans Affairs
- John D. and Catherine T. MacArthur Foundation
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Center for Advancing Translational Sciences