OSBPL3 modulates the immunosuppressive microenvironment and predicts therapeutic outcomes in pancreatic cancer
Our study reveals OSBPL3 as a critical regulator of the immunosuppressive microenvironment in pancreatic cancer and a potential therapeutic target. Targeting OSBPL3 may enhance the efficacy of immunotherapy and improve patient outcomes. Further research is warranted to explore OSBPL3 as a biomarker for predicting immunotherapy response and as a potential therapeutic target in combination with anti-PD1 therapy.
Authors
- Tingting Wen
- Qi Zou (ORCID: https://orcid.org/0000-0003-1792-9150)
- Keping Xie (ORCID: https://orcid.org/0000-0001-7887-9586)
- Xiaoqi Zhu (ORCID: https://orcid.org/0000-0002-3886-8572)
- Yang Chen
- Qihui Sun (ORCID: https://orcid.org/0009-0007-4289-2771)
- Jia Liu (ORCID: https://orcid.org/0000-0001-5678-7437)
- Wei Fang (ORCID: https://orcid.org/0000-0002-2889-9463)
- Tingting Jiang (ORCID: https://orcid.org/0000-0002-5372-0656)
- Xiaojia Li
Institutions
- Guangzhou First People's Hospital (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s13062-025-00596-0
- Citations
- 4
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province