A Phase I Clinical Trial of Intrahepatic Artery Delivery of TG6002 in Combination with Oral 5-Fluorocytosine in Patients with Liver-Dominant Metastatic Colorectal Cancer
In summary, these data demonstrate the delivery of OV to tumor via IHA administration, associated with viral replication and significant peripheral immune activation. Collectively, the data support the need for future studies using IHA administration of OVs.
Authors
- Karen J. Scott (ORCID: https://orcid.org/0000-0002-5790-9579)
- Cristina Smolenschi (ORCID: https://orcid.org/0000-0002-7568-6196)
- Thierry de Baère (ORCID: https://orcid.org/0000-0002-4556-7663)
- Jai V. Patel (ORCID: https://orcid.org/0000-0001-9248-0125)
- Adel Samson (ORCID: https://orcid.org/0000-0002-3081-7850)
- Chris Twelves (ORCID: https://orcid.org/0000-0002-1849-7153)
- Philippe Erbs (ORCID: https://orcid.org/0000-0002-6810-4610)
- Philippe A. Cassier (ORCID: https://orcid.org/0000-0003-3857-1688)
- Kaïdre Bendjama (ORCID: https://orcid.org/0000-0003-2185-9116)
- Fiona Collinson (ORCID: https://orcid.org/0000-0001-6964-6406)
- Christopher Hammond (ORCID: https://orcid.org/0000-0001-9435-5678)
- Alain Sadoun (ORCID: https://orcid.org/0009-0007-7721-6714)
- Sophie Sainte-Croix (ORCID: https://orcid.org/0009-0007-3866-0724)
- Alan A. Melcher (ORCID: https://orcid.org/0000-0002-2042-3380)
- Daniel Swinson (ORCID: https://orcid.org/0000-0002-6186-5759)
- Emma J. West (ORCID: https://orcid.org/0000-0001-7449-120X)
- Marta Kurzawa (ORCID: https://orcid.org/0009-0008-7567-3441)
- Alan Anthoney (ORCID: https://orcid.org/0000-0001-5695-8312)
- Angela Bennett (ORCID: https://orcid.org/0009-0002-8834-8695)
- Ewa Gasior (ORCID: https://orcid.org/0009-0004-8056-024X)
- Sarah Kent (ORCID: https://orcid.org/0009-0004-7350-7934)
- Maud Brandely (ORCID: https://orcid.org/0009-0005-6058-1681)
- Fay Ismail (ORCID: https://orcid.org/0009-0003-2171-5523)
- Edwin M. Banks (ORCID: https://orcid.org/0009-0001-7076-7667)
Institutions
- University of Leeds (GB)
- Institute of Cancer Research (GB)
- Transgene (France) (FR)
- Leeds Teaching Hospitals NHS Trust (GB)
- St James's University Hospital (GB)
- Institut Gustave Roussy (FR)
- Centre Léon Bérard (FR)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2498
- Citations
- 9
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 14.54